if its a wood laminate, you can but you have to be very careful not to go too deep. The laminate might be only 1/16 inch deep and if you sit on it too long with a mechanical sander you will ruin the project.
I would suggest only sand by hand and maybe start with medium and then go to fine. Sand in the direction of the grain and NOT perpendicular.
If formica or synthetic, then you can not sand it. But you can rough it up for painting.