This is alot of suction, but you might need it to move the bad air out and up that tall of a exhaust pipe.
Now, with the door closed and the 300 on, you will not create a vacume by any means. But, you might find a whistle or slight draw noise around the interior door.
If you have adequate ventilation in your attic, meaning turbines, soffet vents and all, have you thought about getting a lesser drawing machine and just dumping it into your attic?
Something to think about.
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