I've landed here searching for the same miracle solution that you all have. I've come to the conclusion that it would be precisely that if there were one. Squeaks are mostly caused by loose nails and can be in the hardwood to subfloor interface or the subfloor to joist interface (if you don't have hardwood floors and have this problem, nail, or preferably screw, the floor down and lay new carpet). The trick is to draw the flooring layers back together so they no longer can slide up and down on the nails. The break off screw is a great idea provided you know where the joists are between the 1st and 2nd floor. I haven't tried them but I can see turning a 2nd level floor into swiss cheese trying to eliminate the problem. There seem to be lots of solutions for this problem if the floor is assessible from below. I honestly don't believe there is a quick fix to this.