...from the start, this is the system that I have had good success with.
1. 3/4" Plywood, screwed and glued to base cabinet.
2. 1/2" Cement board (ie. Wonderboard) cemented to plywood with thinset mortar, and then screwed (make sure screw heads sit down flush with cement board).
3. Tile (floor tile or a heavy mosaic) set with latex modified thinset mortar.
4. Grout (regular polymer modified floor grout ie. Mapei KER200)
5. Seal grout with a quality grout sealer.