I'm no expert but my first instinct is to say no. BUT, then like I said, I'm no expert.
For some reason, I keep 'seeing' a somewhat bouncing floor. I'm not sure if you tile a mobile home like you tile a 'standard home'. This would be a good question to ask the mfgr. of your home. Also, it wouldn't hurt to talk to a few Tile INstallers. After you gather your research, you should be able to make an informed decision. I'd suspec that the answer to your question may 'depend' on things that I/we can't see from here.