You can't fault artist Christoph Niemann for not being bold. Together with his wife, Lisa, Niemann attempted to recreate a pixilated version of a great work of art in his bathroom using four-by-four-inch tile. Read about his selection process and see the final result on his blog. Personally, I liked his kids' bathroom better where the bathroom tile was laid out to recreate the Berlin subway map.
Sometimes we just get in a paradigm and forgot that we can change anything from thinking processes to bathroom renovations. I like unique bathrooms and other rooms where uniqueness and creativity have been firmly planted.